ELK Biotechnology CYP1A2 rabbit pAb
CYP1A2 rabbit polyclonal antibody로 인간, 마우스, 랫트 시료에 반응합니다. IHC, IF, ELISA 등 다양한 응용에 적합하며, 인간 Cytochrome P450 1A2 유래 펩타이드로 면역생성되었습니다. 약물 대사 및 지질 합성 연구용으로 활용됩니다.
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제품명
CYP1A2 rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | CYP1A2; Cytochrome P450 1A2; CYPIA2; Cytochrome P(3)450; Cytochrome P450 4; Cytochrome P450-P3 |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100 - 1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Cytochrome P450 1A2 (AA range: 331–380) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 1544 |
| Human Swiss-Prot No | P05177 |
| Cellular Localization | Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids.
The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke.
The enzyme's endogenous substrate is unknown; however, it can metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates include caffeine, aflatoxin B1, and acetaminophen.
The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3′ untranslated region. [provided by RefSeq, Jul 2008]
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