ELK Biotechnology Sgo1 (phospho Ser14) rabbit pAb
Sgo1 단백질의 Ser14 인산화 부위를 인식하는 토끼 폴리클론 항체. IHC, IF, ELISA에 사용 가능하며, 인간·쥐·마우스 반응성. 세포 분열 시 중심체 및 키네토코어에서의 단백질 위치 연구에 적합. -20°C에서 1년 보관.
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Sgo1 (phospho Ser14) rabbit pAb
제품 개요
ELK Biotechnology의 Sgo1 (phospho Ser14) rabbit pAb는 인간 SGO1 단백질의 Ser14 인산화 부위를 인식하도록 제작된 토끼 폴리클론 항체입니다. 이 항체는 세포 분열 과정에서 중심체 및 키네토코어 단백질의 위치 및 기능 연구에 유용합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Sgo1 (phospho Ser14) rabbit pAb |
| Alternative Names | SGOL1; SGO1; Shugoshin-like 1; hSgo1; Serologically defined breast cancer antigen NY-BR-85 |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | IHC: 1/100–1/300 ELISA: 1/5000 Other applications not yet tested |
| Immunogen | Synthesized peptide derived from human SGO1 around the phosphorylation site of Ser14 (AA range: 1–50) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 151648 |
| Human Swiss-Prot No. | Q5FBB7 |
| Species Reactivity | Human; Rat; Mouse |
| Cellular Localization | Nucleus; Chromosome (centromere, kinetochore); Cytoplasm (spindle pole, centrosome). Localizes to the inner centromere throughout prophase until metaphase and disappears at anaphase. Localization requires BUB1 and PPP2R1A interaction. Colocalizes with NEK2 and SS18L1 at the kinetochore. Phosphorylation by AUKRB and presence of BUB1 are required for kinetochore localization. Isoform 1 primarily localizes to kinetochores during G2 phase and mitosis. |
Background
The protein encoded by this gene belongs to the shugoshin family, which protects centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression leads to premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest. It also protects cohesin along chromosome arms during mitotic prophase. An isoform lacking exon 6 is involved in centriole cohesion. Mutations are associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO) (PMID:25282101).
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