ELK Biotechnology Sgo2 rabbit pAb

제품명

Sgo2 rabbit pAb

주요 정보

세포 내 위치

Nucleus; Chromosome, centromere; Chromosome, centromere, kinetochore.
During meiosis I, accumulates at centromeres during diplotene and colocalizes differentially with cohesin subunits RAD21 and REC8 at metaphase I centromeres (By similarity).
SGO2 and RAD21 change their relative distributions during telophase I when sister-kinetochore association is lost (By similarity).
During meiosis II, it shows tension-dependent redistribution within centromeres throughout chromosome congression during prometaphase II, as it does during mitosis (By similarity).
In HeLa cells, localizes at centromeres throughout prophase until metaphase and disappears at anaphase (PubMed:17485487).
Centromeric localization requires the presence of BUB1 and AUKRB (PubMed:17485487).

Background

• Function: During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Essential for accurate gametogenesis (By similarity).
• Mechanism: May act by targeting PPP2CA to centromeres, leading to cohesin dephosphorylation.
• Post-translational Modification: Phosphorylated upon DNA damage, probably by ATM or ATR.
• Sequence Caution: Contaminating sequence, potential poly-A sequence.
• Similarity: Belongs to the shugoshin family.
• Subunit Interaction: Directly interacts with PPP2CA.