Thermo Fisher Scientific mGluR8 Polyclonal Antibody
mGluR8 단백질을 인식하는 Rabbit Polyclonal 항체로, 인간 및 마우스에서 반응합니다. Western blot에 1:1,000 희석도로 사용 가능하며, 뇌신경 관련 연구에 적합합니다. 액상 형태로 제공되며, 4°C 단기 또는 -20°C 장기 보관이 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 852–882 amino acids from the C-terminal region of human Metabotropic Glutamate Receptor 8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.7 mg/mL |
| Purification | Size-exclusion - Dialysis, Ammonium sulfate precipitation |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2116475 |
Product Specific Information
This antibody is predicted to react with rat based on sequence homology.
Target Information
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions.
The metabotropic glutamate receptors are a family of G protein-coupled receptors, divided into three groups based on sequence homology, signal transduction mechanisms, and pharmacologic properties.
- Group I: GRM1, GRM5 (activate phospholipase C)
- Group II: GRM2, GRM3
- Group III: GRM4, GRM6, GRM7, GRM8
Groups II and III are linked to inhibition of the cyclic AMP cascade but differ in agonist selectivities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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