Thermo Fisher Scientific SPRY2 Polyclonal Antibody

Applications and Tested Dilution

• Western Blot (WB): 0.2–1 µg/mL

Product Specifications

Product Specific Information

• Peptide sequence: MEARAQSGNG SQPLLQTPRD GGRQRGEPDP RDALTQQVHV LSLDQIRAIR
• Sequence homology:
  Cow: 93%
  Dog: 100%
  Guinea Pig: 92%
  Horse: 93%
  Human: 100%
  Mouse: 100%
  Pig: 100%
  Rabbit: 86%
  Rat: 100%

Target Information

This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles.
In primary dermal endothelial cells, this gene is transiently upregulated in response to fibroblast growth factor 2 (FGF2). This protein is indirectly involved in the non-cell autonomous inhibitory effect on FGF2 signaling.
The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. It may play a role in alveoli branching during lung development, as shown by a similar mouse protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.