Thermo Fisher Scientific B7-H3 (CD276) Polyclonal Antibody
Rabbit polyclonal antibody for detection of human B7-H3 (CD276). Suitable for WB and ICC/IF applications. High specificity via antigen affinity purification. Provided in liquid form with stabilizing buffer for reliable long-term storage.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:500 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein within human CD276 (aa 1–466) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.1% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2932573 |
Target Information
CD276, also known as B7-H3, is a member of the B7 family of co-stimulatory molecules. It is a type I transmembrane protein that induces proliferation of CD4+ and CD8+ T cells, enhances cytotoxic T cell generation, and selectively stimulates interferon gamma production. Expression of CD276 can be induced on dendritic cells and monocytes by inflammatory cytokines and is widely expressed in peripheral tissues including the heart, kidney, testis, and colon. In humans, CD276 exists as two isoforms resulting from gene duplication and differential splicing. CD276 has potential therapeutic relevance in regulating cell-mediated immune responses to cancer, particularly in combination with anti-angiogenic therapy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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