Thermo Fisher Scientific PDCD1 Monoclonal Antibody (OTI24D2), TrueMAB

Applications

Product Specifications

Target Information

Cell-mediated immune responses are initiated by T lymphocytes that are stimulated by peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is self-limited as activated T cells express PD-1 (also known as PDCD-1), which mediates inhibitory signals from the APC.
PD-1 binds two ligands, PDL-1 and PDL-2, and upon binding, inhibits activation of immune responses in the absence of danger signals such as LPS or other pathogen-associated molecules.
PD1-deficient mice exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at a higher molecular weight in SDS-PAGE.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.