Thermo Fisher Scientific Apolipoprotein J Monoclonal Antibody (D19)
Thermo Fisher Scientific의 Apolipoprotein J Monoclonal Antibody (D19)은 돼지 단백질 CLU를 인식하는 Mouse IgG1 항체로, WB, IHC, ICC/IF에 사용됩니다. 고순도 Protein A/G 정제, 액상 형태, 높은 안정성의 연구용 항체입니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–20 µg/mL |
| Immunocytochemistry (ICC/IF) | 5–20 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Pig |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | D19 |
| Immunogen | Recombinant Pig CLU protein (Ile229–Glu446, Accession #Q29549) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.05% Proclin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3091310 |
Target Information
Isoform 1 functions as an extracellular chaperone that prevents aggregation of nonnative proteins and stress-induced aggregation of blood plasma proteins. It inhibits amyloid fibril formation by APP, APOC2, B2M, CALCA, CSN3, SNCA, and aggregation-prone LYZ variants (in vitro).
Does not require ATP and maintains partially unfolded proteins for subsequent refolding by other chaperones such as HSPA8/HSC70.
Secreted isoform 1 protects cells against apoptosis and complement-mediated cytolysis.
Intracellular isoforms interact with ubiquitin and SCF E3 ligase complexes, promoting ubiquitination and proteasomal degradation of target proteins.
Modulates NF-kappa-B transcriptional activity, with nuclear isoforms promoting apoptosis and mitochondrial isoforms suppressing BAX-dependent cytochrome c release.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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