Thermo Fisher Scientific Human Akirin1 Synthetic Peptide
Human Akirin1 중심부 14 아미노산 서열로 구성된 합성 펩타이드로, PA5-20606 항체의 블로킹 펩타이드로 사용 가능. NF-κB 의존 유전자 전사 조절 연구에 적합하며, PBS 기반 용액 형태로 제공됨. 연구용 전용 제품.
- 카탈로그번호
- PEP0726
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 14 amino acids near the center of human Akirin1.
PEP-0726 can be used as a blocking peptide with polyclonal antibody PA5-20606.
Target Information
The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-kappa-B-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kappa-B pathways.
Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes.
In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-a and IL-1-b signaling, and for the production of IL-6.
Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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