Thermo Fisher Scientific MACC1 Polyclonal Antibody

Applications and Tested Dilution

• Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200

Product Specifications

Product Specific Information

Immunogen sequence:
FRSGRIAQSM SEANLIDMEA GKLSKSCNIT ECQDPDLLHN WPDAFTLRGN NASKVANPFW NQLSASNPF

• Highest antigen sequence identity to orthologs:
  • Mouse: 57%
  • Rat: 58%

Target Information

MACC1 (Metastasis Associated in Colon Cancer 1) is a key regulator of the hepatocyte growth factor (HGF)-MET receptor pathway, involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis.

• MACC1 protein contains four domains: ZU5, SH3, and two C-terminal death domains (DD).
• Expression is significantly upregulated in malignant tissues (colon cancer, liver, and lung metastases) compared to normal tissues.
• Serves as an early prognostic indicator for colon cancer metastasis, independent of age, sex, tumor infiltration, nodal status, and lymph vessel invasion.
• Involved in MET signaling and apoptosis linkage.
• Potential therapeutic target for colorectal cancer treatment.
• At least two isoforms of MACC1 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.