Thermo Fisher Scientific MACC1 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human MACC1 protein. Validated for IHC (paraffin) applications at 1:50–1:200 dilution. Supplied as liquid, 0.1 mg/mL, purified by antigen affinity chromatography. Stored in PBS with 40% glycerol, 0.02% sodium azid...
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Applications and Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human MACC1. Recombinant protein control fragment: Product #RP-92823 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2643664 |
Product Specific Information
Immunogen sequence:
FRSGRIAQSM SEANLIDMEA GKLSKSCNIT ECQDPDLLHN WPDAFTLRGN NASKVANPFW NQLSASNPF
- Highest antigen sequence identity to orthologs:
- Mouse: 57%
- Rat: 58%
Target Information
MACC1 (Metastasis Associated in Colon Cancer 1) is a key regulator of the hepatocyte growth factor (HGF)-MET receptor pathway, involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis.
- MACC1 protein contains four domains: ZU5, SH3, and two C-terminal death domains (DD).
- Expression is significantly upregulated in malignant tissues (colon cancer, liver, and lung metastases) compared to normal tissues.
- Serves as an early prognostic indicator for colon cancer metastasis, independent of age, sex, tumor infiltration, nodal status, and lymph vessel invasion.
- Involved in MET signaling and apoptosis linkage.
- Potential therapeutic target for colorectal cancer treatment.
- At least two isoforms of MACC1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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