Thermo Fisher Scientific HAVCR2 Monoclonal Antibody (OTI2C11), TrueMAB
Human TIM-3 단백질을 표적으로 하는 Mouse IgG1 단클론 항체. Flow Cytometry에 적합하며, Lyophilized 형태로 제공. 고순도 Affinity chromatography 정제, 연구용으로 면역관용 및 자가면역 질환 연구에 활용 가능.
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Thermo Fisher Scientific HAVCR2 Monoclonal Antibody (OTI2C11), TrueMAB
Applications
- Flow Cytometry (Flow)
Tested Dilution: 1:100
Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2C11 |
| Immunogen | Full length human recombinant protein of human HAVCR2 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-domain containing-3) is a 281 amino acid, Type-1 Th1-specific cell surface glycoprotein expressed on terminally differentiated CD4+ Th1 and CD8+ Tc1 cells.
It consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved tyrosine phosphorylation motif in the cytoplasmic region.
TIM3 is involved in macrophage activation, autoimmune disease induction, and immune tolerance regulation.
Its pathological significance has been noted in Experimental Autoimmune Encephalomyelitis (EAE), a Th1-dependent autoimmune disease.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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