Thermo Fisher Scientific C4BPB Polyclonal Antibody
Thermo Fisher Scientific의 C4BPB Polyclonal Antibody는 인간 C4BPB 단백질을 인식하는 토끼 유래 IgG 항체로, IHC(P) 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며 PBS 기반 완충액에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human C4BPB. Recombinant protein control fragment (Product # RP-94168) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2639059 |
Product Specific Information
Immunogen sequence:
ILGTYVCIKG YHLVGKKTLF CNASKEWDNT TTECRLGHCP DPVLVNGEFS SSGPVNVSDK ITFMCNDHYI LKGSNR
Highest antigen sequence identity to orthologs:
- Mouse: 36%
- Rat: 71%
Target Information
Complement component 4-binding protein (C4BP) is a plasma glycoprotein that inhibits the classical pathway of complement activation, which is mediated through antibody targeting of foreign antigen. Structurally, C4BP is a disulfide-linked, multimeric protein composed of seven alpha chains and one beta chain.
C4BP functions as a cofactor for C3β inactivator in the cleavage of C3β and accelerates the decay of C4βC2α (C3 convertase) by acting as a cofactor in the cleavage of C4β by factor I. Streptococcal strains expressing Ig-binding surface molecules (M protein family) can bind to overlapping C4β binding sites in C4BP, interfering with the classical pathway of complement activation.
Bacteria-bound C4BP may represent an evolved mechanism that downregulates complement activation in the bacterial microenvironment, reducing bacterial opsonization and phagocytosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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