Thermo Fisher Scientific FLT4 Monoclonal Antibody (OTI8C2), TrueMAB
FLT4(VEGFR3) 단백질을 인식하는 마우스 단클론 항체로, Western blot에 최적화되어 있습니다. 고순도의 액상 형태로 제공되며, PBS/BSA/glycerol buffer에 보존됩니다. 인간 시료에 반응하며 연구용으로 적합합니다.
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Applications
- Western Blot (WB): 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI8C2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1063–1363 of human FLT4 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Vascular endothelial growth factor (VEGF) is a key regulator of blood vessel development in embryos and angiogenesis in adult tissues. Unlike VEGF, the related VEGFC stimulates lymphatic vessel growth through its specific lymphatic endothelial receptor VEGFR-3.
In 1998, Dumont demonstrated that targeted inactivation of the VEGFR-3 gene in mice resulted in defective blood vessel development in early embryos. Although vasculogenesis and angiogenesis occurred, large vessels became abnormally organized with defective lumens, leading to fluid accumulation in the pericardial cavity and cardiovascular failure at embryonic day 9.5.
Thus, VEGFR3 plays an essential role in the development of the embryonic cardiovascular system prior to the emergence of lymphatic vessels.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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