Thermo Fisher Scientific NBN Monoclonal Antibody (OTI2F5), TrueMAB
인간 NBN 단백질을 인식하는 마우스 단클론 항체. Western blot과 IHC(파라핀) 분석에 적합. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공. 연구용으로만 사용 가능.
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Thermo Fisher Scientific NBN Monoclonal Antibody (OTI2F5), TrueMAB
Applications and Tested Dilution
- Western Blot (WB): 1:2,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2F5 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 183–460 of human NBN produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The p95 gene (identical to NBS1 and nibrin) is part of the hMre11/hRad50 double-strand break complex. This complex is associated with Nijmegen breakage syndrome, an autosomal recessive disorder characterized by increased cancer susceptibility, cell cycle checkpoint defects, and sensitivity to ionizing radiation. These findings demonstrate a direct molecular link between double-strand break repair and cell cycle checkpoint functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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