Thermo Fisher Scientific Human KPNA6 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 13 amino acids near the amino terminus of human KPNA6.
PEP-1150 can be used as a blocking peptide with polyclonal antibody PA5-21036.

Target Information

Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism.
The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC.
KPNA6 belongs to a subfamily within the KPNA family that also includes IPOA5&6.
Down-regulation of KPNA6 by RNAi expression in HeLa cells strongly inhibited cell proliferation, possibly due to blocking the nuclear import of specific factors essential for cell growth and proliferation.
KPNA6 also interacts with the Rev protein of HIV-1 and promotes its nuclear import.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.