Thermo Fisher Scientific Human KPNA6 Synthetic Peptide
인간 KPNA6의 아미노 말단 13개 아미노산 서열에 해당하는 합성 펩타이드입니다. 항체 PA5-21036과 함께 블로킹 펩타이드로 사용 가능합니다. 정제된 액상 형태로 제공되며 PBS 완충액에 0.1% BSA와 0.02% sodium azide가 포함되어 있습니다. 연구용 시약으로 진단용 사용 불가.
- 카탈로그번호
- PEP1150
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
Product Specific Information
This peptide corresponds to 13 amino acids near the amino terminus of human KPNA6.
PEP-1150 can be used as a blocking peptide with polyclonal antibody PA5-21036.
Target Information
Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism.
The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC.
KPNA6 belongs to a subfamily within the KPNA family that also includes IPOA5&6.
Down-regulation of KPNA6 by RNAi expression in HeLa cells strongly inhibited cell proliferation, possibly due to blocking the nuclear import of specific factors essential for cell growth and proliferation.
KPNA6 also interacts with the Rev protein of HIV-1 and promotes its nuclear import.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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