Thermo Fisher Scientific ZRANB2 Polyclonal Antibody
ZRANB2 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, WB 및 ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. 액상 형태, 1 mg/mL 농도, 아피니티 크로마토그래피로 정제. 핵 내 스플라이싱 인자 ZNF265 검출에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ZRANB2 (Accession O95218), corresponding to amino acid residues Y124–D174 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | −20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2900782 |
Product Specific Information
Antibody detects endogenous levels of total ZNF265.
Target Information
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which involve transcriptional activation or repression.
ZNF265 (Zinc finger protein 265), also known as ZRANB2 (Zinc finger Ran-binding domain-containing protein 2), ZIS, ZIS1, or ZIS2, is a 330 amino acid protein belonging to the ZRANB2 family.
Localized to the nucleus, ZNF265 functions as a splicing factor responsible for alternative splicing of Tra-2 beta transcripts and may interfere with constitutive 5′-splice selection.
ZNF265 contains two RanBP2-type zinc fingers that mediate RNA-binding activity. Two isoforms, ZIS-1 and ZIS-2, are expressed due to alternative splicing events. Upon DNA damage, ZIS-2 may be phosphorylated by ATM or ATR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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