Thermo Fisher Scientific Human RANBP10 Synthetic Peptide
인간 RANBP10 단백질의 중심부 15개 아미노산 서열 기반 합성 펩타이드로, 항체 차단 실험에 활용 가능. PBS 완충액에 0.1% BSA 포함, 200 µg/mL 농도. 연구용으로만 사용.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 15 amino acids near the center of human RANBP10.
PEP-1044 can be used as a blocking peptide with polyclonal antibody PA5-20930.
Target Information
The RAN binding protein 10 (RANBP10) is a cytoplasmic guanine nucleotide exchange factor that shares high sequence similarity to the MET-interacting protein RANBP9. RANBP10 is expressed in the cytoplasm of mature megakaryocytes (MKs) and platelets, where it localizes to polymerized noncentrosomal microtubules.
RANBP10 possesses guanine nucleotide exchange factor activity towards RAN, a GTPase involved in nucleocytoplasmic traffic, spindle formation at mitosis, and nuclear envelope assembly during telophase. This suggests that RANBP10 may also be involved in these activities.
RANBP10 depletion in vitro caused disturbance of polymerized filaments in MKs, and platelets in RANBP10- mice exhibited disorders in microtubule filament numbers and localization, indicating that RANBP10 may play a significant role in maintaining microtubule dynamics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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