Thermo Fisher Scientific ATP2C2 Polyclonal Antibody
Human ATP2C2 단백질을 인식하는 Rabbit Polyclonal Antibody. IHC(P)에서 1:200–1:500 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제된 비결합 항체. PBS, 40% glycerol 용액에 보관, 단기 4°C, 장기 -20°C 보관 권장. 연구용 전용 시약.
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ATP2C2. Recombinant protein control fragment (Product # RP-95779) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.6 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2638359 |
Product Specific Information
Immunogen sequence:
LEKDEEEALI DEQSELKAIE KEKKVTALPP KEACKCQKED LARAFCVDLH TGLSEFSVTQ RRLAHGWNEF VADNSEPVWK KYLDQ
- Highest antigen sequence identity to orthologs:
- Mouse: 78%
- Rat: 76%
Target Information
ATP2C2, also known as secretory pathway Ca²⁺/Mn²⁺-ATPase (SPCA2), belongs to the family of P-type cation transport ATPases.
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytosol to the Golgi lumen.
Defects in the related gene ATP2C1 cause Hailey-Hailey disease, for which ATP2C2 does not compensate, suggesting that ATP2C2 plays other physiological roles.
Unlike ATP2C1, ATP2C2 has a more restricted expression pattern and displays a higher maximal turnover rate for Ca²⁺-ATPase reaction and a lower apparent affinity for cytosolic Ca²⁺ activation of phosphorylation.
Overexpression of ATP2C2 in mammary tumors results in Ca²⁺ influx via the store-operated Ca²⁺ channel ORAI1, independent of STIM1 and STIM2 sensors.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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