Thermo Fisher Scientific ATP2C2 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) [IHC (P)]

• Tested Dilution: 1:200–1:500

Product Specifications

Product Specific Information

Immunogen sequence:
LEKDEEEALI DEQSELKAIE KEKKVTALPP KEACKCQKED LARAFCVDLH TGLSEFSVTQ RRLAHGWNEF VADNSEPVWK KYLDQ

• Highest antigen sequence identity to orthologs:
  • Mouse: 78%
  • Rat: 76%

Target Information

ATP2C2, also known as secretory pathway Ca²⁺/Mn²⁺-ATPase (SPCA2), belongs to the family of P-type cation transport ATPases.
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytosol to the Golgi lumen.

Defects in the related gene ATP2C1 cause Hailey-Hailey disease, for which ATP2C2 does not compensate, suggesting that ATP2C2 plays other physiological roles.
Unlike ATP2C1, ATP2C2 has a more restricted expression pattern and displays a higher maximal turnover rate for Ca²⁺-ATPase reaction and a lower apparent affinity for cytosolic Ca²⁺ activation of phosphorylation.
Overexpression of ATP2C2 in mammary tumors results in Ca²⁺ influx via the store-operated Ca²⁺ channel ORAI1, independent of STIM1 and STIM2 sensors.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.