Thermo Fisher Scientific APOBR Monoclonal Antibody (OTI1B1), TrueMAB
APOBR 단백질을 인식하는 Mouse IgG1 단클론 항체로 Western blot과 IHC(P)에서 검증됨. 동결건조 형태로 제공되며, PBS buffer(8% trehalose) 내 보존. 재구성 후 약 1 mg/mL 농도로 사용 가능. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 780–1088 of human APOBR produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, an additional desalting step is recommended (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
APOBR is a macrophage receptor that binds to apolipoprotein B48 (APOB) of dietary triglyceride-rich lipoproteins (TRL) or similar domains in APOB of hypertriglyceridemic VLDL (HTG-VLDL).
It binds and internalizes TRL outside the macrophage context, potentially providing essential lipids to reticuloendothelial cells.
It may also contribute to foam cell formation under elevated TRL and remnant lipoprotein (RLP) conditions.
Mediates rapid, high-affinity uptake of chylomicrons (CM), HTG-VLDL, and trypsinized VLDL (devoid of APOE) in vitro in macrophages.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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