Thermo Fisher Scientific SIRT1 Monoclonal Antibody (OTI5B2)
SIRT1 단백질을 인식하는 Thermo Fisher Scientific의 단일클론 항체로, WB, IHC, ICC/IF에 적합합니다. Human, Mouse, Rat 반응성을 가지며, 고순도 친화 크로마토그래피로 정제되었습니다. -20°C 보관, 연구용 전용 제품입니다.
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- MA527217
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2,000 | - |
| Immunocytochemistry (ICC/IF) | 1:100 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5B2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 552–676 of SIRT1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2723650 |
Target Information
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) links transcriptional regulation directly to intracellular energetics and participates in the coordination of several cellular functions such as cell cycle, DNA damage response, metabolism, apoptosis, and autophagy.
SIRT1 modulates chromatin function through histone deacetylation and can promote alterations in histone and DNA methylation, leading to transcriptional repression.
It is essential in skeletal muscle cell differentiation and mediates inhibitory effects under low nutrient conditions involving AMPK and NAMPT.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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