Thermo Fisher Scientific NALP11 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human NALP11. Recombinant protein control fragment (Product #RP-99200). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NALP11,uniProtId:P59045-1,ncbiNodeId:9606,antigenRange:928-1030,antigenLength:1033,antigenImageFileName:PA5-61235_NALP11_P59045-1_Rabbit.svg,antigenImageFileNamePDP:PA5-61235_NALP11_P59045-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2644450

Product Specific Information

Immunogen sequence: HLGNDGVAKL LESLISPDCV LKVVGLPLTG LNTQTQQLLM TVKERKPSLI FLSETWSLKE GREIGVTPAS QPGSIIPNSN LDYMFFKFPR MSAAMRTSNT ASR

Highest antigen sequence identity to the following orthologs: Mouse - 23%, Rat - 23%.

Target Information

NALP11 is a 1033 amino acid containing cytoplasmic protein belonging to the NLRP family with a DAPIN domain, six LRR (leucine-rich) repeats and a NACHT domain. Reports suggest that it is a short NALP involved in inflammation potential. NALP proteins are implicated in the activation of proinflammatory caspases (e.g., CASP1) via their involvement in multiprotein complexes called inflammasomes. The DAPIN domain is necessary and sufficient for suppression of NF-kappa B activation induced by TNF and for inducing IL-1B secretion in collaboration with Caspase-1. It is involved in interaction with PYCARD.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.