Thermo Fisher Scientific MC4 Receptor Polyclonal Antibody, FITC
MC4 수용체를 인식하는 FITC 표지 폴리클로날 항체로, WB, IHC, ELISA, IP에 사용 가능. 인간, 마우스, 랫트 반응성. 친화 크로마토그래피 정제, 액상 형태. -20°C 암소 보관, 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 10–60 on human MC4R protein |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8) with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Expression of MC4R has been reported in the brain. Unlike other melanocortin receptors, MC4R is not expressed in the adrenal cortex or melanocytes.
G-protein Coupled Receptors (GPCRs) represent one of the largest families of signaling molecules, sharing a structural motif of seven membrane-spanning helices. GPCRs exist in active and inactive forms, with various ligands influencing their conformation and downstream signaling via G-proteins.
Regulation of GPCR activity plays a critical role in cellular physiology and pharmacological research, contributing to the development of major GPCR-targeted drugs such as Zyprexa (Eli Lilly) and Claritin (Schering-Plough).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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