Thermo Fisher Scientific Frunevetmab Recombinant Feline Monoclonal Antibody

Applications

• ELISA (ELISA): Assay-dependent

Product Specifications

Product Specific Information

• Endotoxin level: < 0.01 EU/µg by LAL method
• Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
• Store at 2–8°C for one week.
• Store at -20 to -80°C for twelve months from the date of receipt.

Target Information

Frunevetmab is a biosimilar that targets NGF (Nerve Growth Factor). NGF influences the survival and differentiation of various neuronal and nonneuronal cells. It binds to specific cell surface receptors with both high and low affinity sites, but only the high-affinity receptor mediates signal transduction.

Cross-linking studies with 125I-NGF have shown that the high-affinity receptor of rat PC12 cells forms an Mr 158,000 complex with NGF, while the low-affinity receptor forms an Mr 100,000 complex. Full-length cDNA clones for both human and rat NGF receptor genes show over 90% homology. NGF exhibits nerve growth-stimulating activity and regulates the growth and differentiation of sympathetic and sensory neurons. Mutations in the NGF gene are associated with hereditary sensory and autonomic neuropathy type 5 (HSAN5), and dysregulation of NGF expression is linked to allergic rhinitis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.