Thermo Fisher Scientific UBE2T Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

Immunoprecipitation (IP)

1-5 µL/mg of lysate

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

E. coli-derived Human UBE2T fragment

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Antigen affinity chromatography, Protein A

Storage buffer

PBS, pH 7

Contains

0.03% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2902927

Target Information

UBE2T is involved in the covalent conjugation of ubiquitin to proteins regulates diverse cellular pathways and proteins. Ubiquitin is transferred to a target protein through a concerted action of a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), such as UBE2T, and a ubiquitin ligase (E3). UBE2T catalyzes the covalent attachment of ubiquitin to protein substrates. Functionally, UBE2T accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins, catalyzes monoubiquitination, is involved in mitomycin-C (MMC)-induced DNA repair, and catalyzES monoubiquitination of FANCD2, a key step in the DNA damage pathway. Defects in the UBE2T gene have been associated with Fanconi anemia of complementation group T.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.