Thermo Fisher Scientific GeneBLAzer HCRTR2-Gα15-NFAT-bla CHO-K1 Cells
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| 카탈로그 번호 | CAS 번호 | 설명 | 상태 | 단위 | 판매가 | 할인가 | 가격(VAT포함) | 수량 / 장바구니 / 찜 |
| K1737 | - | Thermo Fisher Scientific K1737 GeneBLAzer HCRTR2-Gα15-NFAT-bla CHO-K1 Cells Each pk | 재고문의 | pk | 0원 | - | 0원 | |
다른 상품 둘러보기
Thermo Scientific™
GeneBLAzer™ HCRTR2-Gα15-NFAT-bla CHO-K1 Cells
GeneBLAzer™ HCRTR2-Gα15-NFAT-bla CHO-K1 cells contain the human Orexin Receptor B (HCRTR2) stably integrated into the GeneBLAzer™ Gα15-NFAT-bla CHO-K1 cell line.자세히 알아보기
GeneBLAzer™ HCRTR2-Gα15-NFAT-bla CHO-K1 cells contain the human Orexin Receptor B (HCRTR2) stably integrated into the GeneBLAzer™ Gα15-NFAT-bla CHO-K1 cell line. GeneBLAzer™ Gα15-NFAT-bla CHO-K1 cells (Cat. No. K1537) contain a beta-lactamase reporter gene under control of the Nuclear Factor of Activated T-cells (NFAT) response element and the Promiscuous G protein, Gα15.
The GeneBLAzer™ HCRTR2-Gα15-NFAT-bla CHO-K1 cells are functionally validated for Z` and EC50 concentrations of Orexin B. In addition, GeneBLAzer™ HCRTR2-Gα15-NFAT-bla CHO-K1 cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.
The HCRTR2 receptor has been detected in the brain as well as adrenal gland, gastrointestinal tract, and pancreas. The signaling cascades used by orexin receptors appear to be varied and cell type dependant. In CHO cells, calcium release is seen after agonist treatment. In hypothalamic neurons, the frequency of action potentials is increased. Administering either orexin peptide into the bloodstream of rats caused an increase in feeding behavior. The orexin system is also thought to regulate neuroendocrine function and the sleep wake cycle. HCRTR2 has been directly implicated in narcolepsy in animal studies.
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사양
등록 번호NM_001526.2
어세이 입력Cell-based beta lactamase reporter gene
셀 상태Dividing Cells
검출 방법Fluorescence
용도(애플리케이션)FRET
유전자 기호HCRTR2
개체군 상태Single Cell Clone Origin
제품라인GeneBLAzer™
수량2 x 106 Cells
리포터 유전자BLA (Beta-Lactamase)
타겟 입력HCRTR2
세포주CHO-K1
System TypeGeneBLAzer™
Druggable TargetGPCR
Unit SizeEach
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