Thermo Fisher Scientific SWAP70 Polyclonal Antibody
SWAP70 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF, ELISA 등에 사용 가능. Human, Mouse, Rat 반응성. 고순도 Protein A 정제, 액상 형태로 -20°C 보관.
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Thermo Fisher Scientific SWAP70 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human SWAP70, amino acids 131–230 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.03% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
SWAP70 is a 585 amino acid regulatory protein belonging to the pleckstrin-like family with a PH domain essential for phosphatidylinositol 3,4,5-trisphosphate binding.
It acts as a link between the recognition of specific switch regions and causation of a DNA break and is involved in both nuclear events and signaling B-cell activation.
As a guanine nucleotide exchange factor (GEF), it transduces signals from tyrosine kinase receptors to RAC, independent of RAS.
SWAP70 mediates signaling of membrane ruffling by tyrosine kinase growth factor receptors, actin cytoskeleton, and cell protrusion.
It is widely expressed in most tissues, including mature B-cells, monocytes, and macrophages.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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