Thermo Fisher Scientific CDK2AP1 Polyclonal Antibody

Thermo Fisher Scientific CDK2AP1 Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution

• 1:500–1:1,000

Publications

• References

Product Specifications

Target Information

The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2)-associated protein that negatively regulates CDK2 activity by sequestering monomeric CDK2 and targeting CDK2 for proteolysis.
It also interacts with DNA polymerase alpha/primase and mediates phosphorylation of the large p180 subunit, suggesting a regulatory role in DNA replication during the S-phase.
Additionally, this protein forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex, which epigenetically regulates embryonic stem cell differentiation.
This gene plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.