Thermo Fisher Scientific GPNMB Monoclonal Antibody (1A8)
GPNMB 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot과 ELISA에 사용 가능. 인간 시료 반응성. PBS(pH 7.4) 용액 형태로 제공되며 방부제 무첨가. -20°C 보관, 동결/해동 반복 피할 것.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 0.3 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1A8 |
| Immunogen | GPNMB (NP_001005340, 104–203 a.a.) partial recombinant protein with GST tag. MW of GST tag alone is 26 kDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
RCQKEDANGN IVYEKNCRNE AGLSADPYVY NWTAWSEDSD GENGTGQSHH NVFPDGKPFP HHPGWRRWNF IYVFHTLGQY FQKLGRCSVR VSVNTANVTL
Target Information
The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein.
GPNMB shows expression in lowly metastatic human melanoma cell lines and xenografts but not in highly metastatic cell lines.
It may be involved in growth delay and reduction of metastatic potential.
Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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