Thermo Fisher Scientific PLA1A Polyclonal Antibody
PLA1A 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot, IHC, ICC/IF에 적합하며 인간, 마우스, 랫트 시료에서 반응. 고순도 친화 크로마토그래피 정제 및 안정한 PBS/glycerol 저장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PLA1A (Accession Q53H76), corresponding to amino acid residues I257–I307 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853590 |
Product Specific Information
Antibody detects endogenous levels of total PLA1A.
Target Information
PLA1A is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine.
This secreted protein hydrolyzes phosphatidylserine (PS) in liposomes and can also hydrolyze PS in apoptotic cells and activate platelets, where the resulting 2-acyl-lysophosphatidylserine acts as a lipid mediator for mast cells, T cells, and neural cells.
A major function of PLA1A may be the production of lysophospholipid mediators.
PLA1A is upregulated in rat peripheral blood cells bearing long-term surviving cardiac allograft. It is also expressed in human THP-1-derived macrophages, and this expression is upregulated in cells treated with lipopolysaccharide (a TLR4 ligand). This upregulation is inhibited with corticosteroids, which are often used at high dosages to suppress chronic allograft rejection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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