Thermo Fisher Scientific Phospho-Slingshot homolog 1 (Ser976) Polyclonal Antibody

Thermo Fisher Scientific Phospho-Slingshot homolog 1 (Ser976) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering chromatin structure.
The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin.
It possesses at least two conserved domains important for function:

1. A DNA-binding domain that specifically binds AT-rich sequences recognized by SNF/SWI complex at the beta-globin locus.
2. A C-terminal domain that stimulates glucocorticoid receptor-dependent transcriptional activation.

The protein may confer specificity to the SNF/SWI complex and recruit it to targets through protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.