Thermo Fisher Scientific COP1 Polyclonal Antibody
인간 COP1 단백질에 특이적인 Rabbit Polyclonal Antibody로 IHC(Paraffin) 검증 완료. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성 제공. 염증 관련 Caspase-1 조절 연구에 적합. 연구용으로만 사용 가능.
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Thermo Fisher Scientific COP1 Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P))
Tested Dilution: 1:20–1:50
Publications: - [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human COP1. Recombinant protein control fragment (Product #RP-101616) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2640056 |
Product Specific Information
Immunogen sequence:LHKGSLYPRI PGLGKELQTG THKLS
Highest antigen sequence identity to the following orthologs:
- Mouse: 48%
- Rat: 48%
Target Information
Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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