Thermo Fisher Scientific GBL Polyclonal Antibody
Thermo Fisher Scientific의 GBL Polyclonal Antibody는 인간 GBL 단백질을 인식하는 토끼 유래 IgG 항체로, Western blot에 적합합니다. 고순도 항원 친화 크로마토그래피로 정제되었으며, 다양한 종에 높은 예측 반응성을 보입니다. 연구용으로만 사용됩니다.
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Applications
- Western Blot (WB): 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to amino acids 102–326 of Human G protein beta subunit like (GBL) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2548270 |
Product Specific Information
- Recommended positive controls: HeLa, 293T, A431, Jurkat, Raji
- Predicted reactivity: Mouse (97%), Rat (97%), Zebrafish (91%), Xenopus laevis (88%), Bovine (99%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
G-protein beta subunit like (GBL protein) is a novel member of the WD-40 protein family. It is a highly conserved cytosolic protein consisting of seven WD-40 repeating motifs.
LST8 is a functional component of the mTOR signaling complex (TORC1) and positively regulates the mTOR pathway. It interacts with the kinase domain of mTOR and stabilizes its interaction with raptor.
LST8 participates in regulating cell growth and nutrient- and growth factor-mediated mTOR signaling to S6K1. Reports suggest up-regulated expression of LST8 due to insulin, indicating a possible role in intracellular events related to insulin-receptor activation, including insulin-stimulated glucose transport and glycogen synthesis.
Northern blot analysis detected ubiquitous expression of LST8 with highest expression in brain and testis.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(PA5-30796_GBL_Q9BVC4-1_Rabbit.svg 및 PA5-30796_GBL_Q9BVC4-1_Rabbit_PDP.jpeg)
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