Thermo Fisher Scientific GBL Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:3,000

Product Specifications

Product Specific Information

• Recommended positive controls: HeLa, 293T, A431, Jurkat, Raji
• Predicted reactivity: Mouse (97%), Rat (97%), Zebrafish (91%), Xenopus laevis (88%), Bovine (99%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

G-protein beta subunit like (GBL protein) is a novel member of the WD-40 protein family. It is a highly conserved cytosolic protein consisting of seven WD-40 repeating motifs.
LST8 is a functional component of the mTOR signaling complex (TORC1) and positively regulates the mTOR pathway. It interacts with the kinase domain of mTOR and stabilizes its interaction with raptor.
LST8 participates in regulating cell growth and nutrient- and growth factor-mediated mTOR signaling to S6K1. Reports suggest up-regulated expression of LST8 due to insulin, indicating a possible role in intracellular events related to insulin-receptor activation, including insulin-stimulated glucose transport and glycogen synthesis.
Northern blot analysis detected ubiquitous expression of LST8 with highest expression in brain and testis.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(PA5-30796_GBL_Q9BVC4-1_Rabbit.svg 및 PA5-30796_GBL_Q9BVC4-1_Rabbit_PDP.jpeg)