Thermo Fisher Scientific Granzyme B Polyclonal Antibody, Biotin
Human 및 비인간 영장류 반응성의 Granzyme B 폴리클로날 항체로, Biotin 결합 형태. Western blot, IHC, ELISA, IP 등 다양한 응용 가능. 합성 펩타이드(aa 50-100) 기반 면역원으로 제작. 고순도 친화 크로마토그래피 정제 및 안정적 액상 형태.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 50–100 on human endogenous Granzyme B protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8) with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Granzyme B is a member of the granzyme serine protease family found in the granules of cytotoxic T cells and NK cells. It plays a key role in inducing apoptosis in target cells through caspase activation and mitochondrial pathways. Granzyme B interacts with the mannose 6-phosphate receptor, functioning as a death receptor during cytotoxic T cell-induced apoptosis. It can cleave caspase-3 and Bid protein to trigger DNA fragmentation and cell death. Granzymes are neutral serine proteases stored in specialized lytic granules of CTLs and NK cells. Several granzymes (A–G) have been cloned from mice, while fewer have been identified in humans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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