Thermo Fisher Scientific Phospho-MAP2K4 (Thr261) Polyclonal Antibody
MAP2K4(Thr261) 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot에 최적화되어 있으며, MEK1/2/3과 교차 반응하지 않습니다. 항원 친화 크로마토그래피로 정제된 액상 형태의 연구용 항체입니다.
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide corresponding to residues around pThr261 of human SEK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10978887 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with the corresponding phosphorylated residues of MEK1, MEK2, or MKK3.
Target Information
MAP2K4 (MEK4) serine/threonine kinase (mitogen-activated protein kinase 4) is a dual specificity kinase of the STE7 family that phosphorylates and activates JNK1 and JNK2 as well as p38.
MAP2K4 preferentially phosphorylates the tyrosine residue of JNKs and mediates various physiological and pathophysiological processes such as responses to cellular stresses and inflammatory cytokines.
MAP2K4 plays an important role in carcinogenesis; loss-of-function mutations have been identified in lung and pancreatic tumors, while pro-oncogenic roles have also been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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