Thermo Fisher Scientific Connexin 46 Polyclonal Antibody
마우스 Connexin 46 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, WB, IHC(F), ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 형태이며, 렌즈 세포 연구에 적합. 연구용으로만 사용.
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Thermo Fisher Scientific Connexin 46 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 2 µg/mL |
| Immunocytochemistry (ICC/IF) | 2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from an internal region of the mouse Connexin 46 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533385 |
Product Specific Information
38-8300 detects Cx46 in IHC application in cryostat sections of adult mouse lens.
Target Information
Connexin 46 (Cx46), also known as Gap Junction Protein Alpha-3 (GJA3), CAE3, CX46 and C2P3, maps to human chromosome 13q11-q12 and encodes a 46 kDa protein.
Cx46, along with Cx50, is principally expressed in the lens of the eye. It mediates intercellular interactions during development and is necessary for the survival of neural crest cells.
Cx46 forms gap junctions that connect lens fiber cells and are crucial for maintaining lens transparency and normal lens function.
Mutations of Cx46 result in severe cataracts of the lens. Individual knockouts of Cx46 and Cx50 lead to changes in the rate of lens fiber cell differentiation and cell size, indicating that their interaction is required for proper organization of fiber cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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