Thermo Fisher Scientific MLH1 Monoclonal Antibody (OTI2D12), TrueMAB
MLH1 단백질을 표적하는 고특이성 단클론 항체로 인간, 생쥐, 랫트 시료에 반응합니다. Western blot에 최적화되어 있으며, PBS 기반 버퍼에 동결건조 형태로 제공됩니다. DNA 복제 불일치 복구 연구 및 MSI 관련 연구에 적합합니다.
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2D12 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 299–527 of human MLH1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
MLH1 is a DNA mismatch repair protein essential for maintaining genetic integrity. Defects in mismatch repair pathways can lead to microsatellite instability (MSI), which is associated with carcinogenesis, including hereditary nonpolyposis colon cancer (HNPC).
MSH2 recognizes mismatch nucleotides during replication, and MLH1 forms a heterodimer with PMSH to facilitate subsequent repair steps.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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