Thermo Fisher Scientific IKBKE Polyclonal Antibody
IKBKE 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC, ELISA 등 다양한 응용 가능. 고순도 Protein A 정제, 안정적인 액상 형태로 제공. 연구용으로 NF-κB 활성 관련 연구에 적합.
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Thermo Fisher Scientific IKBKE Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human IKBKE (amino acids 501–600) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
IKBKE is an activator of nuclear factor-kappa-B (NF-κB). Overexpression of IKBKE has been observed in breast cancer cells, and suppression of IKBKE induces cell death.
NF-κB is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses.
NF-κB mediates the expression of various genes in response to extracellular stimuli and is associated with IκB proteins in the cytoplasm, which inhibit NF-κB activity.
IκB is phosphorylated by the IκB kinase (IKK) complex containing IKK-α, IKK-β, and IKK-γ.
A novel molecule in the IKK complex, IKK-iota/IKK-i (IKKε), is required for activation of NF-κB by PMA and T cell receptors but not by TNF-α or IL-1.
IKK-iota/IKK-i message is expressed in various tissues and is inducible by TNF-α, IL-1, and LPS.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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