Thermo Fisher Scientific Calnexin Monoclonal Antibody (3H4A7)

Thermo Fisher Scientific Calnexin Monoclonal Antibody (3H4A7)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA5-15389 targets Calnexin in indirect ELISA, IF, and WB applications and shows reactivity with Human samples.
The immunogen is a synthetic peptide corresponding to aa (CEAAEERPWLWVVYILTVAL) of human Calnexin, conjugated to KLH.
MA5-15389 detects Calnexin, which has a predicted molecular weight of approximately 90 kDa.

Target Information

Calnexin (also known as IP90, p88, and p90) is an approximately 90 kDa integral membrane protein of the endoplasmic reticulum (ER).
It functions as a molecular chaperone involved in the proper folding and assembly of polypeptides and multisubunit proteins.
Calnexin associates with MHC class I heavy chains, partial complexes of the T cell receptor and B cell membrane immunoglobulin, but not with completed receptor complexes.
It retains incompletely or improperly folded proteins in the ER.
Soluble ER resident proteins such as GRP78, GRP94, and protein disulfide isomerase contain a KDEL sequence for ER retention, whereas integral membrane proteins like calnexin lack this sequence but have positively charged cytosolic residues ensuring ER retention.
Calnexin consists of a large ER luminal domain (461 amino acids), a transmembrane segment (22 amino acids), and a cytoplasmic tail (89 amino acids).

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.