Thermo Fisher Scientific C5AR1 Monoclonal Antibody (P12/1)

Applications

• Western Blot (WB): Assay-dependent
• Immunohistochemistry (Paraffin) (IHC (P)): Assay-dependent
• Immunohistochemistry (Frozen) (IHC (F)): Assay-dependent
• Flow Cytometry (Flow): Assay-dependent

Product Specifications

Product Specific Information

Mouse anti Human CD88 antibody, clone P12/1 recognizes the C5a receptor (C5aR), also known as CD88 or C5a anaphylatoxin chemotactic receptor 1.
CD88 is predominantly expressed on cells of the myeloid lineage. When C5aR is preincubated with C5a, this antibody does not bind to the receptor, as the binding site of P12/1 is located in the C5a binding region (Werfel et al., 1996; Weinman et al., 2003).

Target Information

CD88 (C5aR1) is a C5a Anaphylatoxin Receptor that mediates the effects of one of the most potent chemotactic agents known.
C5AR1 is implicated in asthma and expressed in myeloid blood cells, brain, liver, lung, spleen, heart, kidney, and intestinal tract.
CD88 binds the inflammatory peptide anaphylatoxin C5a, stimulating chemotaxis, granule enzyme release, and superoxide anion production.
It is also part of the classical complement cascade and may contribute to tissue injury associated with ischemia or sepsis.
Diseases associated with CD88 include Mannose-Binding Lectin Deficiency and Systemic Lupus Erythematosus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.