Thermo Fisher Scientific GABRA1 (extracellular) Polyclonal Antibody
GABRA1 단백질의 세포외 영역을 인식하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC에 사용 가능하며, Lyophilized 형태로 제공. -20°C 보관, 0.8 mg/mL 농도. 신경전달 관련 GABA 수용체 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:400–1:1,000 |
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide QPSQDELKDNTTVFTR(C), corresponding to amino acid residues 28–43 of rat GABA(A) alpha1 Receptor |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.8 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2735804 |
Product Specific Information
Product is shipped at room temperature as a lyophilized powder and should be stored at -20°C upon receipt.
Reconstitution: add 50 µL of deionized water.
Target Information
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing hyperpolarization of the membrane through the opening of a Cl⁻ channel associated with the GABAA Receptor (GABAA-R) subtype.
GABAA-Rs are important therapeutic targets for sedative, anxiolytic, and hypnotic agents and are implicated in diseases such as epilepsy, anxiety, depression, and substance abuse.
The GABAA-R is a multimeric subunit complex composed of multiple alpha, beta, and gamma subunits, including splice variants. Expression of alpha and beta subunits results in functional GABAA-R sensitive to GABA, while coexpression of a gamma subunit is required for benzodiazepine modulation.
Phosphorylation of beta subunits has been shown to modulate GABAA-R function.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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