Thermo Fisher Scientific SGOL1 Polyclonal Antibody
Human SGOL1 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P)에서 1:20~1:50 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS(40% glycerol) 버퍼에 보존. SGOL1 단백질의 세포 분열 관련 기능 연구에 적합.
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Applications
Tested Applications and Dilutions
- Immunohistochemistry (Paraffin) (IHC (P)): 1:20–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SGO1. Recombinant protein control fragment (Product #RP-105490) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Lot-specific |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2791977 |
Product Specific Information
Immunogen sequence:
TASVNYKEPT LASKLRRGDP FTDLCFLNSP IFKQKKDLRR SKKRALEVSP AKEAIFILYY VREFVSRFPD CRKCKLETH
Target Information
The protein encoded by this gene is a member of the shugoshin family of proteins. It protects centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression leads to premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest.
Evidence suggests that this protein also protects a subset of cohesin along chromosome arms during mitotic prophase.
An isoform lacking exon 6 plays a role in centriole cohesion. Mutations in this gene are associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO).
Fibroblast cells from CAID patients show increased proliferation and higher rates of senescence. Pseudogenes have been found on chromosomes 1 and 7. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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