Thermo Fisher Scientific Phospho-ZAP70/Syk (Tyr319, Tyr352) Recombinant Rabbit Monoclonal Antibody (Zap70Y319-A3)
ZAP70 및 Syk 단백질의 Tyr319/Tyr352 인산화 부위를 인식하는 재조합 토끼 단일클론 항체. 높은 특이성과 재현성을 제공하며, Flow Cytometry 등 다양한 응용에 적합. PBS 기반 안정화 용액에 보관되며, 연구용으로만 사용 가능.
- 카탈로그번호
- MA536961
- 판매단위
- pk
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 1–1,000 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | Zap70Y319-A3 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Tyr319/Tyr352 of human phospho Zap70/Syk |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2896896 |
Additional Formats
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the large rabbit immune repertoire
Target Information
ZAP-70 is a cytosolic protein tyrosine kinase of the Syk family, expressed in T-cells and natural killer cells, essential for T-cell receptor activation.
Upon TCR engagement, ZAP70 is phosphorylated at tyrosines 292, 315, and 319 within the interdomain B region.
- Tyr315: Vav binding site
- Tyr319: Lck binding site
Phosphorylation at these sites enhances ZAP70-mediated lymphocyte signaling, while Tyr292 phosphorylation attenuates activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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