Thermo Fisher Scientific Z DNA binding protein Polyclonal Antibody
Z-DNA binding protein 1(ZBP1)에 특이적인 Rabbit Polyclonal Antibody로, WB, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. Human 및 Mouse 반응성 확인. KLH 접합 합성 펩타이드(aa 301-400) 면역원 사용. 고순도 Protein A 정제, 액상 형태, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Z DNA binding protein, amino acids 301–400 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Z-DNA binding protein 1 (ZBP1) belongs to a family of proteins that contain the Zα domain, which binds specifically to left-handed Z-DNA and Z-RNA. ZBP1 was initially identified as a gene up-regulated in activated macrophages in mice bearing ascites tumors, suggesting a role in host response during neoplasia.
Recent studies indicate that cytosolic ZBP1 can act similarly to toll-like receptor TLR9 by detecting cytosolic double-stranded DNA and inducing type I interferon and other innate immune responses.
Binding of ZBP1 to dsDNA enhances its association with innate immune response proteins such as IRF3 and TBK1. Multiple isoforms of ZBP1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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