Thermo Fisher Scientific ITGA3 Polyclonal Antibody
Thermo Fisher Scientific의 ITGA3 Polyclonal Antibody는 인간 및 랫트 반응성을 가지며 Western blot과 IHC에 적합합니다. 항원 친화 크로마토그래피로 정제된 비결합 항체로, PBS/glycerol 완충액에 보존됩니다. 신경세포 이동 및 세포 접착 관련 연구에 활용됩니다.
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- PA582356
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ITGA3 (CD49c, Integrin alpha 3, UniProt ID: P26006-2, antigen range: 600–725). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789515 |
Product Specific Information
Immunogen sequence:
AQALENHTEV QFQKECGPDN KCESNLQMRA AFVSEQQQKL SRLQYSRDVR KLLLSINVTN TRTSERSGED AHEALLTLVV PPALLLSSVR PPGACQANET IFCELGNPFK RNQRMELLIA FEVIGV
Target Information
ITGA3 (Integrin, Alpha-3)
Also known as CD49C, VLA3, or GAPB3, ITGA3 is a cell surface adhesion molecule encoded by the ITGA3 gene located on chromosome 17q21.33. It forms half of the α3β1 integrin duplex, which plays a role in neural migration and corticogenesis alongside the β1 subunit.
DAB1 phosphorylation and ITGA3 signaling are linked to the detachment of migrating neurons from radial glial fibers. Expression of human ITGA3 increases viral infectivity in Chinese hamster ovary cells.
ITGA3 contains 13 potential N-glycosylation sites, 2 potential cleavage sites, and 7 N-terminal repeating units typical of integrins. Recombinant ITGA3 is expressed as a 150-kDa protein, similar to the native form observed in Western blot analysis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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