Thermo Fisher Scientific RIN1 Polyclonal Antibody
RIN1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(P)에서 검증됨. 항원 친화 크로마토그래피로 정제되었으며, PBS buffer(40% glycerol, 0.02% sodium azide) 내 액상 형태로 제공. 인간 시료에 반응하며 연구용으로 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human RIN1. Recombinant protein control fragment (Product #RP-96524). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2646568 |
Product Specific Information
Immunogen sequence:
RLPTTGYLVY RRAEWPETQG AVTEEEGSGQ SEARSRGEEQ GCQGDGDAGV KASPRDIREQ SETTAEGGQG QAQEGPAQPG EP
Highest antigen sequence identity to the following orthologs:
- Mouse – 39%
- Rat – 40%
Target Information
Rit and its neuron-specific homologue, Rin, define a recently discovered subfamily of Ras-related GTPases. Rit and Rin are membrane-associated despite lacking a CAAX box or similar C-terminal lipidation motif. They display 64% amino acid sequence identity and share a unique nine amino acid effector domain (DPTIEDAYK) that is 100% conserved between murine and human proteins.
Although the effector domain sequences of Rit and Rin are similar to that of Ras, Rit and Rin interact with Ras-binding proteins RalGDS, Rlf, and AF-6, but not with Raf kinases, RIN1, or the p110 subunit of PI3 kinase. It has been suggested that Rit and Rin may play roles in signaling pathways distinct from those controlled by Ras.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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