Thermo Fisher Scientific CD83 Monoclonal Antibody (3F3)

Applications

Product Specifications

Product Specific Information

Protein Sequence:

MSRGLQLLLL SCAYSLAPAT PEVKVACSED VDLPCTAPWD PQVPYTVSWV KLLEGGEERM ETPQEDHLRG QHYHQKGQNG SFDAPNERPY SLKIRNTTSC NSGTYRCTLQ DPDGQRNLSG KVILRVTGCP AQRKEETFKK YRAEIVLLLA LVIFYLTLII FTCKFARLQS IFPDFSKAGM ERAFLPVTSP NKHLGLVTPH KTELV

Target Information

CD83 cell surface antigen is a 40–45 kDa glycoprotein expressed by peripheral blood dendritic cells. Peripheral lymphocytes can express low levels of CD83 after stimulation with Con A or PHA.
In immunohistology, CD83 is strongly expressed by interfollicular interdigitating reticulum cells and weakly by germinal centre cells. It is also expressed by Langerhans cells in the skin.

CD83 antigen is a 186-amino-acid single-chain glycoprotein belonging to the immunoglobulin superfamily, composed of:

• Extracellular V-type Ig-like domain
• Transmembrane region
• Short cytoplasmic tail (~40 amino acids)

CD83 undergoes extensive post-translational glycosylation, resulting in a molecular weight twice that of the core protein.
CD83⁺ cells exhibit a unique surface phenotype distinct from T, B, NK, or myelomonocytic cells, and coexpress high levels of MHC class II molecules along with various lineage markers (CD2, CD5, CD40, CD78, CD13, CD33, CD36).

Diseases associated with CD83 dysfunction include plague and Rift Valley Fever.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.