Thermo Fisher Scientific Human Flt-3 Ligand (FLT3L) Recombinant Protein, PeproTech
Human Flt-3 Ligand (FLT3L) 재조합 단백질로, 인간 AML5 세포 증식을 자극하는 생물학적 활성이 높은 시약입니다. E. coli 발현 시스템에서 제조되었으며 ≥98%의 고순도와 낮은 엔도톡신 함량을 갖습니다. 면역세포 분화 및 DC 연구용으로 적합합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | View 1 publication |
| Flow Cytometry (Flow) | – | View 1 publication |
| ELISA | Assay-dependent | – |
| Functional Assay | Assay-dependent | – |
| In vitro Assay | – | View 403 publications |
| Miscellaneous PubMed | – | View 42 publications |
| Immunostaining (IS) | – | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Published species | Hamster, Human, Mouse, Non-human primate, Rabbit, Rat |
| Expression System | E. coli |
| Amino Acid Sequence | TQDCSFQHSP ISSDFAVKIR ELSDYLLQDY PVTVASNLQD EELCGGLWRL VLAQRWMERL KTVAGSKMQG LLERVNTEIH FVTKCAFQPP PSCLRFVQTN ISRLLQETSE QLVALKPWIT RQNFSRCLEL QCQPDSSTLP PPWSPRPLEA TAPTA |
| Molecular Weight | 17.6 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 98% by SDS-PAGE gel and HPLC analyses |
| Endotoxin Concentration | <1 EU/µg |
| Activity | ED50 ≤ 1.0 ng/ml (specific activity ≥ 1 x 10^6 units/mg, based on AML5 cell proliferation) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
Recombinant Human Flt3-Ligand is a soluble 17.6 kDa protein consisting of 155 amino acid residues.
This product is shipped at ambient temperature. For storage, handling, and reconstitution information, please refer to the lot-specific Certificate of Analysis.
Target Information
Gene: FLT3LG (Fms Related Tyrosine Kinase 3 Ligand)
Function: Protein coding gene associated with cytokine activity and protein homodimerization activity.
Related Diseases: Aplastic Anemia, Brain Cancer
Pathways: Hematopoietic Stem Cell Differentiation, Lineage-specific Markers, Ras signaling pathway
Dendritic cells (DCs) serve as a key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG regulates the development of DCs, particularly plasmacytoid DCs and CD8-positive classical DCs, as well as their CD103-positive tissue counterparts.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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