Thermo Fisher Scientific CD366 (TIM3) Monoclonal Antibody (F38-2E2), PE, eBioscience
인간 CD366(TIM3)을 인식하는 F38-2E2 단클론 항체로, PE 형광 표지되어 흐름세포분석(Flow Cytometry)에 최적화됨. 활성화된 T세포, 단핵구, 수지상세포 등에서 TIM3 발현 분석에 활용. 4°C 암소 보관, 동결 금지.
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Thermo Fisher Scientific CD366 (TIM3) Monoclonal Antibody (F38-2E2), PE, eBioscience™
Applications
- Flow Cytometry (Flow)
Tested dilution: 5 µL (0.125 µg)/test
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | F38-2E2 |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2572604 |
Available Formats
- Alexa Fluor 532
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Brilliant UV 805
- Brilliant Violet 605
- Brilliant Violet 650
- Brilliant Violet 786
- FITC
- Functional Grade
- PE-Cyanine5
- PE-Cyanine5.5
- PE-Cyanine7
- PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Super Bright 645
- Super Bright 702
- Super Bright 780
- Request custom conjugation
Product Specific Information
This F38-2E2 monoclonal antibody reacts with human CD366, also known as T cell immunoglobulin and mucin domain-containing protein 3 (TIM3) or HAVCR2.
CD366 is expressed on activated CD4+ T cell subsets (Th1, Th17, Treg), CD8+ T cells, monocytes, dendritic cells, and mast cells.
Galectin-9 is identified as the ligand for CD366. In humans, this receptor negatively regulates CD4+ T cells, influencing Th1- and Th17-related cytokine secretion.
CD366 is implicated in tolerance, autoimmune disease (e.g., multiple sclerosis), and HIV infection.
Applications Reported: Flow cytometric analysis.
Applications Tested: Pre-titrated and validated for flow cytometric analysis of stimulated normal human peripheral blood cells.
Use at 5 µL (0.125 µg) per test (defined as staining a 100 µL cell sample).
Cell number range: 10⁵–10⁸ cells/test.
Excitation: 488–561 nm
Emission: 578 nm
Compatible Lasers: Blue, Green, Yellow-Green
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
TIM3 (HAVCR2) is a 281 amino acid, type I Th1-specific cell surface glycoprotein expressed on terminally differentiated CD4+ Th1 and CD8+ Tc1 cells.
TIM3 contains an IgV-like domain, a mucin-like domain, and a conserved tyrosine phosphorylation motif.
It is involved in macrophage activation, autoimmune disease induction, and immune tolerance regulation.
Pathological significance includes experimental autoimmune encephalomyelitis (EAE) and Th1-mediated immune response modulation.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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