Thermo Fisher Scientific DCLK3 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 207-321. Recombinant protein control fragment (Product #RP-109973). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:DCLK3,uniProtId:Q9C098-1,ncbiNodeId:9606,antigenRange:207-321,antigenLength:648,antigenImageFileName:PA5-144847_DCLK3_Q9C098-1_Rabbit.svg,antigenImageFileNamePDP:PA5-144847_DCLK3_Q9C098-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.6 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_3091900

Product Specific Information

Immunogen sequence: PRNPTQELRR PSKSMDKKED RGPEDQESHA QGAAKAKKDL VEVLPVTEEG LREVKKDTRP MSRSKHGGWL LREHQAGFEK LRRTRGEEKE AEKEKKPCMS GGRRMTLRDD QPAKL

Antigen sequence identity: Mouse 53%; Rat 56%

Target Information

DCLK3 is one of three doublecortin-like kinases similar to the Ca2+/calmodulin-dependent protein kinase (CaMK) family. DCLK3 mRNA, like that of the homologous DCLK1 and DCLK3, is highly expressed in adult brain, but only DCLK3 transcripts are present in liver and kidney, suggesting that DCLK3 may play other roles than in cortical development. The DCLK proteins are homologous to Doublecortin (DCX), a protein that is mutated in X-linked human lissencephaly. In mouse models where the DCX gene has been disrupted, DCLK1 expression increases slightly and appears to compensate for the loss of DCX, as mice mutant for both DCX and DCLK1 show a severe phenotype including perinatal lethality, disorganized neocortical layering, and profound hippocampal cytoarchitectural disorganization.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.