Thermo Fisher Scientific NCOA4 Monoclonal Antibody (439CT10.4.4)
인간 NCOA4 단백질을 인식하는 Mouse IgM 단일클론 항체로 Western blot에 최적화되어 있습니다. 비결합형 액상 형태이며 0.25 mg/mL 농도로 제공됩니다. 단기 보관은 4°C, 장기 보관은 -20°C에서 권장됩니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific NCOA4 Monoclonal Antibody (439CT10.4.4)
Applications
- Western Blot (WB)
Tested Dilution: 1:100–1:250
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgM |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 439CT10.4.4 |
| Immunogen | Purified His-tagged NCOA4 protein (fragment) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Euglobulin precipitation |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897485 |
Target Information
Androgen receptor (AR) coactivator ARA70, also designated NCOA4, RFG and ELE1, is a putative co-activator that specifically enhances the activity of the androgen receptor.
In human thyroid carcinomas, the Ret proto-oncogene fuses to ARA70 to form Ret/PTC3 by an intrachromosomal inversion in vivo.
ARA70 is expressed as two isoforms, ARA70a and ARA70b. The shorter variant, ARA70b, results from an internal 985-bp deletion.
ARA70a is widely expressed, with highest expression in testis and adipose tissues, whereas ARA70b is solely expressed in the testis.
ARA70a can function as a ligand-enhanced co-activator of PPARγ in adipocytes.
ARA70 may be involved in prostate carcinogenesis and ovarian cancer and may serve as a key mediator of estrogen-androgen synergism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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